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25 UMBILICAL CORD STEM CELLS - A REALITY TODAY, A FUTURE FULL OF POSSIBILITIES The first Umbilical Cord Blood (UCB) Stem Cell transplant was performed in 1988 and, since then, more than 30,000 transplants have been performed worldwide. Around the globe, hundreds of clinical trails are being undertaken to evaluate the use of umbilical cord blood in treating hematologic and non-hematologic diseases. UCB Stem Cells can be used in Autologous (same person's stem cells) or Allogeneic (donor's stem cells) transplants, including Stem Cells from a sibling or other family member. In 1997 a study proved that one-year survival rate is more than twice as high if patient receives a cord blood stem cell transplant from a relative (63%) vs. an unrelated donor (29%). (Gluckman et al, 1997) UMBILICAL CORD BLOOD ACTUAL USE IN MODERN MEDICINE 100% 80% 60% 40% 20% 0% 63% 29% SURVIVAL RATE: UMBILICAL CORD BLOOD TRANSPLANTS Related Umbilical Cord Blood Transplantation Unrelated Umbilical Cord Blood Transplantation E. Gluckman et al. (1997) N. Engel, J.Med 100% 80% 60% 40% 20% 0% 3% 42% GRAFT vs HOST: UMBILICAL CORD BLOOD TRANSPLANTS Related Unrelated Kutzberg (1996), Wagner (1995), Laghlin (2001)

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